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Call key data
Novel culturing of aquatic organisms for blue biotechnology applications
Call number
HORIZON-CL6-2023-CircBio-01-11
deadlines
Opening
22.12.2022
Deadline
28.03.2023 17:00
Deadline - 2nd stage
Opening
25.01.2023
Funding rate
100%
Call budget
€ 8,000,000.00
Estimated EU contribution per project
€ 4,000,000.00
Link to the call
Link to the submission
Call content
Call objectives
The biotechnological exploitation of both pelagic and benthic marine and other aquatic (such as the ones living in fresh waters, transitional waters and ice ecosystems) organisms often requires their cultivation and the optimisation of production yield for the compounds of interest. Aquatic biota, and in particular marine ones (bacteria, algae, fungi or invertebrates such as sponges, corals and molluscs), cannot be easily cultured. It is believed that just a fraction of 1% of marine bacteria can be cultured using existing methods, and viruses and bacterial and viral phages, present even greater challenges. The culturing of aquatic organisms offers a sustainable alternative to wild harvesting. The potential environmental footprint and impact on health, sustainability and biodiversity aspects need, nevertheless, to be thoroughly assessed and safety established, through risks analysis linked to possible dissemination of newly developed organisms in nature. Culturing methods should be developed in sealed conditions, such completely in vitro or in aquaria and mesocosms, with particular attention to avoid spread of non-indigenous species in the natural aquatic environment.
Proposals under this topic should:
- Develop culturing methods (including for mixed cultures) for vertebrate and invertebrate cell lines for the production of active compounds particularly based on co-metabolism between community members that represent a radical change from the conventional “isolate and enrich” approach to cell culture;
- Develop bio-engineering tools for the use of marine and other aquatic model organisms to improve the availability of metabolites for industrial applications;
- Optimise culturing conditions so that the relevant metabolites are appropriately expressed and can be recovered with selective downstream processing techniques.
Selected projects should collaborate with each other. In this topic the integration of the gender dimension (sex and gender analysis) in research and innovation content is not a mandatory requirement.
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Expected results
- Expansion of the potential offered by marine or other aquatic biological resources through advances based on the greater knowledge of the functioning, processes and ecological interactions of marine and other aquatic organisms;
- Development of aquatic biotechnology solutions in cultivation and optimisation of production yield;
- Increased bio discovery of products through sustainable methods for robust aquatic bio-based production, including possibly production of chassis cells, as an alternative to wild harvesting;
- Support to green industrial bioprocessing and more sustainable bio-based products through new biotechnology processes and applications;
- Contribution to the development of circular processing.
Eligibility Criteria
Regions / countries for funding
Moldova (Moldova), Albania (Shqipëria), Armenia (Հայաստան), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Faeroes (Føroyar / Færøerne), Georgia (საქართველო), Iceland (Ísland), Israel (ישראל / إِسْرَائِيل), Kosovo (Kosova/Kosovë / Косово), Montenegro (Црна Гора), Morocco (المغرب), North Macedonia (Северна Македонија), Norway (Norge), Serbia (Srbija/Сpбија), Tunisia (تونس /Tūnis), Türkiye, Ukraine (Україна), United Kingdom
eligible entities
EU Body, Education and training institution, International organization, Natural Person, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)
Mandatory partnership
Yes
Project Partnership
To be eligible for funding, applicants must be established in one of the following countries:
- the Member States of the European Union, including their outermost regions
- the Overseas Countries and Territories (OCTs) linked to the Member States
- third countries associated to Horizon Europe - see list of particpating countries
Only legal entities forming a consortium are eligible to participate in actions provided that the consortium includes, as beneficiaries, three legal entities independent from each other and each established in a different country as follows:
- at least one independent legal entity established in a Member State; and
- at least two other independent legal entities, each established in different Member States or Associated Countries.
Any legal entity, regardless of its place of establishment, including legal entities from non-associated third countries or international organisations (including international European research organisations) is eligible to participate (whether it is eligible for funding or not), provided that the conditions laid down in the Horizon Europe Regulation have been met, along with any other conditions laid down in the specific call topic.
A ‘legal entity’ means any natural or legal person created and recognised as such under national law, EU law or international law, which has legal personality and which may, acting in its own name, exercise rights and be subject to obligations, or an entity without legal personality.
Specific cases:
- Affiliated entities — Affiliated entities (i.e. entities with a legal or capital link to a beneficiary which participate in the action with similar rights and obligations to the beneficiaries, but which do not sign the grant agreement and therefore do not become beneficiaries themselves) are allowed, if they are eligible for participation and funding.
- Associated partners — Associated partners (i.e. entities which participate in the action without signing the grant agreement, and without the right to charge costs or claim contributions) are allowed, subject to any conditions regarding associated partners set out in the specific call conditions.
- Entities without legal personality — Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees to protect the EU’s financial interests equivalent to those offered by legal persons.
- EU bodies — Legal entities created under EU law including decentralised agencies may be part of the consortium, unless provided for otherwise in their basic act.
- Joint Research Centre (‘JRC’)— Where provided for in the specific call conditions, applicants may include in their proposals the possible contribution of the JRC but the JRC will not participate in the preparation and submission of the proposal. Applicants will indicate the contribution that the JRC could bring to the project based on the scope of the topic text. After the evaluation process, the JRC and the consortium selected for funding may come to an agreement on the specific terms of the participation of the JRC. If an agreement is found, the JRC may accede to the grant agreement as beneficiary requesting zero funding or participate as an associated partner, and would accede to the consortium as a member.
- Associations and interest groupings — Entities composed of members (e.g. European research infrastructure consortia (ERICs)) may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. However, if the action is in practice implemented by the individual members, those members should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible.
other eligibility criteria
Activities are expected to achieve TRL 3-5 by the end of the project.
For the Technology Readiness Level (TRL), the following definitions apply:
- TRL 1 — Basic principles observed
- TRL 2 — Technology concept formulated
- TRL 3 — Experimental proof of concept
- TRL 4 — Technology validated in a lab
- TRL 5 — Technology validated in a relevant environment (industrially relevant environment in the case of key enabling technologies)
- TRL 6 — Technology demonstrated in a relevant environment (industrially relevant environment in the case of key enabling technologies)
- TRL 7 — System prototype demonstration in an operational environment
- TRL 8 — System complete and qualified
- TRL 9 — Actual system proven in an operational environment (competitive manufacturing in the case of key enabling technologies, or in space)
Additional information
Topics
Relevance for EU Macro-Region
EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region
UN Sustainable Development Goals (UN-SDGs)
Additional Information
All proposals must be submitted electronically via the Funders & Tenders Portal electronic submission system (accessible via the topic page in the Search Funding & Tenders section). Paper submissions are NOT possible.
Proposals must be complete and contain all parts and mandatory annexes and supporting documents, e.g. plan for the exploitation and dissemination of the results including communication activities, etc.
The application form will have two parts:
- Part A (to be filled in directly online) contains administrative information about the applicant organisations (future coordinator and beneficiaries and affiliated entities), the summarised budget for the proposal and call-specific questions;
- Part B (to be downloaded from the Portal submission system, completed and then assembled and re-uploaded as a PDF in the system) contains the technical description of the project.
Annexes and supporting documents will be directly available in the submission system and must be uploaded as PDF files (or other formats allowed by the system).
The limit for a full application (Part B) is 45 pages.
Call documents
HE-Work Programme 2023-2024, Cluster 6, Destination 3HE-Work Programme 2023-2024, Cluster 6, Destination 3(463kB)
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