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Call key data

European partnership for pandemic preparedness

Funding Program

Horizon Europe - Cluster 1 - Destination 3: Tackling diseases and reducing disease burden

Call number

HORIZON-HLTH-2024-DISEASE-12-01

deadlines

Opening
25.04.2024

Deadline
26.11.2024 17:00

Funding rate

30-70%

Call budget

€ 100,000,000.00

Estimated EU contribution per project

€ 100,000,000.00

Link to the call

ec.europa.eu

Link to the submission

ec.europa.eu

Call content

short description

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”. The partnership will be firmly anchored within the framework of the European Health Union package that aims to improve the EU's capacity in the vital areas of prevention, preparedness, surveillance, risk assessment, early warning, and response. In this regard, synergies and close collaboration with the European Health Emergency Preparedness and Response Authority (HERA) and other relevant European Commission services need to be ensured.

Call objectives

The COVID-19 pandemic uncovered the challenges that European health care systems face in detecting, preventing, combatting and managing outbreaks of infectious diseases in a coordinated manner. It also illustrated the need for stronger preparedness and networks for research and timely clinical trials and observational studies, for more timely availability of medical countermeasures, such as vaccines, therapeutics and diagnostics, as well as more appropriate non-pharmaceutical interventions and adequate communication strategies in terms of fighting mis/disinformation and fostering appropriate behaviours. Furthermore, it showed how unilateral research initiatives may lead to a fragmented, inefficient research landscape.

At the same time, the relentless work of the research community that has led to availability of several COVID-19 vaccines in record time highlighted the critical importance of collaborative R&I to respond rapidly to emerging health threats.

Therefore, transformative investments in research for pandemic preparedness are needed at European level. Stronger collaboration and coordination between European actors, including the appropriate infrastructures and networks, are an important prerequisite for improving EU’s pandemic preparedness and stepping up our contribution to global cooperation in this area.

This should be done through a partnership that promotes:

  • improved coordination and cooperation to adjust research and innovation agendas on national and European levels (and contributing globally), as essential part of the pandemic preparedness planning and implementation activities;
  • coordination and prioritisation of a comprehensive research response to a health emergency, from basic research for better understanding of pathogens with pandemic potential to the development or adaptation of medical countermeasures, as well as effective non-pharmaceutical interventions (NPI) and/or public health and social measures (PHSM), and using an integrated One Health approach;
  • the consolidation and further development of ever-warm EU-wide networks and infrastructures for clinical research, controlled trials and observational studies for public health interventions, such as EU-wide vaccine and treatment trials, PHSM/NPI trials or cohorts;
  • the provision of robust and timely scientific evidence to inform sound public health decision-making in response to a public health emergency;
  • the use of agreed data standards to safely collect, store, link and manage FAIR data and to exploit the full potential of the generated data for modelling and in-silico methods for epidemic surveillance, clinical trials and observational studies, among others.

The partnership should strengthen the European Research Area by supporting excellence in innovative research, capacity building, programmes for development of talent, widening the engagement of countries and sectors not yet involved.

The partnership should endorse a pandemic preparedness Strategic Research and Innovation Agenda (SRIA) based on the work of the CSA BE READY and prepare for the management of the research response during a crisis, by strengthening the collaboration between relevant partners and the alignment of related investments. The partnership will consider the impact of environmental, climatic issues and patterns in relation with the emergence and spread of health threats to better understand how these increase the risk for emerging infectious diseases, and how this should be integrated into the research done using a One Health approach.

The scope of the partnership should encompass:

  • basic research to accelerate the acquisition of knowledge on the biology of pathogens with epidemic or pandemic potential, their transmission and interaction with humans, animals and plants, in particular in view of emerging threats to human health. The initial focus should be on pathogens with high epidemic or pandemic potential for the EU, such as those included in the list of priority diseases of the World Health Organization (WHO), with particular attention to those meeting the criteria identified by HERA;
  • preclinical research aimed at better understanding of human diseases caused by pathogens with epidemic or pandemic potential and testing of related medical countermeasures;
  • clinical research to support the generation of novel solutions, in particular the development (phase I to phase III) of medical countermeasures, e.g. vaccines, diagnostics, therapeutics and digital solutions, to prevent or mitigate outbreaks from pathogens with epidemic or pandemic potential, in line with the mission of HERA and the ACT EU initiative;
  • a key feature should be the consolidation and further development of an ever-warm network of clinical trial sites applying the same quality standards and ensuring a baseline of continuous clinical trial activity across a wide and diverse range of clinical trial sites, to allow for a rapid clinical trial response in case of an epidemic or pandemic. This includes the development of criteria for a clinical trial site to be considered as ever-warm;
  • the development, testing and validation of new methods and tools, including those based on artificial intelligence and computer modelling, to improve surveillance and diagnosis and control of the spread of pathogens with epidemic or pandemic potential;
  • the conduct of public health and social sciences and humanities (SSH) research for the development and robust evaluation of appropriate non-pharmaceutical interventions/public health and social measures and effective communication strategies at all phases of a public health emergency;
  • the consolidation and/or development of infrastructures, platforms and networks necessary for fast and timely start of the response research, capitalising on previous investments and existing infrastructures supporting collaboration, trans-boundary access and provision of services, such as provided by ISIDORe or ECRIN.
  • capacity building through networking and training of researchers, to share knowledge and good practices also with EU and national entities, policymakers and funders.

It is intended to implement the partnership in two phases. The activities in the first phase should mainly focus on:

  • the way clinical trials are set up and conducted in the EU to address public health emergencies, including new approaches such as computer modelling and in-silico clinical trials.
    • this will require coordination mechanisms to support prioritisation of emergency trials, improved mechanisms to identify and rank promising compounds, mobilising EU and Member State funding mechanisms, and measures to help speed up contracting of clinical trial sites during emergencies and in preparedness time. For this purpose, close collaboration with the EMA and its Emergency Task Force, National Competent Authorities, Ethics Committees, and the European Commission should be ensured.
    • this includes the consolidation, integration and further expansion of EU-wide network of ever-warm clinical trial sites, building on earlier made investments such as Vaccelerate, Ecraid and EU RESPONSE. It is expected that the partnership will develop a sustainable solution to ensure the long-term viability of adequate European clinical trial networks for a timely public health emergency response, which cover key target populations and have a suitable geographic spread.
  • implementing joint calls for transnational proposals to foster transnational research in the other areas in the scope of the partnership.
  • developing the roadmaps for the implementation of the remaining activities foreseen by the partnership.

The second phase of the partnership is expected to build on this first phase, to further develop and consolidate what has been achieved and implement the roadmaps developed for remaining activities as outlined in the scope, with the possibility of expanding to new partners.

The total indicative budget for the partnership is up to EUR 100 million and subject to the effective implementation of the commitments made by the members of the consortium. The Commission envisages to include new actions in its future work programmes to provide continued support to the partnership for the duration of Horizon Europe.

The expected duration of the partnership is 7 to 10 years with the first phase having a duration of 2 to 3 years.

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Expected effects and impacts

As general principles, the partnership will:

  • promote an inclusive membership and balanced geographic representation, open to third countries and other relevant stakeholders;
  • promote data sharing, data standards and data-based digital tools, and align with EU-wide initiatives on open access and FAIR data, artificial intelligence and virtual human twins;
  • pay specific attention to the gender and sex dimensions, as well as representativeness of different population groups including young people and vulnerable groups;
  • foster the development and use of trustworthy artificial intelligence, in all its three dimensions (lawful, ethical and robust);
  • ensure synergies and explore collaborations with other relevant activities at EU and international level.

To ensure coherence and complementarity of activities and leverage knowledge and investment possibilities, the partnership is expected to establish relevant collaborations with the relevant European Commission services, with other Horizon Europe projects, partnerships (institutionalised and co-funded) and missions as set out in the working document on ‘Coherence and Synergies of candidate European partnerships under Horizon Europe’ as well as to explore collaborations with other relevant activities at EU and international level. On top of this, the proposal should consider synergies with EU programmes, including but not limited to EU4Health, the Digital Europe Programme (DIGITAL), the European Social Fund Plus (ESF+), the European Regional Development Fund (ERDF), InvestEU, the Recovery and Resilience Facility (RRF) and the Technical Support Instrument (TSI).

When defining calls for proposals, the partnership needs to consider the effective contribution of social sciences and humanities (SSH) disciplines and the involvement of SSH experts, institutions as well as the inclusion of relevant SSH expertise, in order to produce meaningful and significant effects enhancing the societal impact of the related research activities.

The partnership should create synergies with the European and Developing Countries Clinical Trials Partnership (EDCTP) currently in its third iteration as Global Health EDCTP3 Joint Undertaking, that brings together 15 countries from Europe and 25 countries from sub-Saharan Africa. EDCTP is already funding adaptive clinical trial networks spanning African and European countries and a Clinical Trials Community Network The partnership should also contribute to help achieve the goals of GloPID-R, the coalition of research funders that invests in research to improve pandemic preparedness & response.

The partnership is open to all EU Member States, as well as to countries associated to Horizon Europe and will remain open to third countries wishing to join. Applicants should describe in their proposal the methodology for their collaboration and the aims they want to achieve with this kind of collaboration. Cooperation with international organisations, private sector and non-European institutions and experts may be considered.

Governance

The partnership’s governance structure should enable an upfront strategic steering, effective management and coordination, daily implementation of activities and ensure the use and uptake of the results. The governance should involve key stakeholders and interested parties, including but not limited to the research and innovation community, public health authorities, patients and citizens, health and care professionals, formal and informal care organisations, innovation owners, and relevant EU entities, including the European Commission, the European Centre for Disease Prevention and Control and the European Medicines Agency.

Resources

The proposal should pool the necessary cash and in-kind resources from the participating national (or regional) research programmes, in order to:

  • sustain and further develop the EU-wide networks and infrastructures for clinical research, and in particular a network of ever-warm clinical trial sites by running continuous preparedness trials in relevant target populations;
  • implement joint calls for transnational proposals resulting in grants to third parties. Financial support provided by the participants to third parties is one of the activities of this action in order to be able to achieve its objectives;
  • conduct capacity building activities;
  • implement any other activities, coordinated between (a group of) partnership members, that contribute to the achievement of the partnership’s objectives. Research projects resulting from coordinated national calls could be envisaged in this context as well.

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Expected results

The partnership’s activities are expected to be key enablers of the EU Global Health Strategy, notably its guiding principle 5 to boost global health research and guiding principle 7 to strengthen capacities for prevention, preparedness and response, particularly to expand and strengthen European and global research partnerships including clinical trial networks that can be pivoted to address new and emerging pathogens.

Proposals under this topic should aim for delivering results that are directed, tailored towards, and contributing to all of the following expected outcomes:

  • The EU offers a valued network of clinical trial sites that have the capacity to implement well-coordinated large-scale multi-country quality trials in different target populations, which are able to smoothly transition to public health interventions relevant for cross-border health threats in response to a public health emergency;
  • Relevant EU and national entities, the scientific communities and networks, policymakers and funders enhance their collaboration and coordination for strengthened research on pandemic preparedness and response, forming a strong and structured ecosystem with shared evidence, tools and methodologies cutting across sectors;
  • Research funders, policymakers, relevant EU and national entities, and the research community recognise and close rapidly relevant research and related infrastructure gaps and break existing silos on pandemic preparedness research and response;
  • Healthcare authorities, regulatory authorities, policymakers and other stakeholders use the research results to develop evidence-based strategies and policies for pandemic preparedness and response, and deploy good practices to European countries and regions, and beyond whenever relevant;
  • The research community at large benefits from and uses an improved comprehensive knowledge framework integrating the EU, national/regional data and information infrastructures to improve transnational research in the area of pandemic preparedness and response;
  • The EU is strengthened as an internationally recognised actor for pandemic preparedness research and response, as such substantially contributing to global cooperation and coordination.

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Eligibility Criteria

Regions / countries for funding

EU Member States, Overseas Countries and Territories (OCT)
Moldova (Moldova), Albania (Shqipëria), Armenia (Հայաստան), Azerbaijan (Azərbaycan), Belarus (Беларусь), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Faeroes (Føroyar / Færøerne), Georgia (საქართველო), Iceland (Ísland), Israel (ישראל / إِسْرَائِيل), Kosovo (Kosova/Kosovë / Косово), Montenegro (Црна Гора), Morocco (المغرب), New Zealand (Aotearoa), North Macedonia (Северна Македонија), Norway (Norge), Serbia (Srbija/Сpбија), Tunisia (تونس /Tūnis), Türkiye, Ukraine (Україна), United Kingdom

eligible entities

Education and training institution, International organization, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)

Mandatory partnership

Yes

Project Partnership

To be eligible for funding, applicants must be established in one of the following countries:

  • the Member States of the European Union, including their outermost regions
  • the Overseas Countries and Territories (OCTs) linked to the Member States
  • third countries associated to Horizon Europe - see list of particpating countries

Only legal entities forming a consortium are eligible to participate in actions provided that the consortium includes, as beneficiaries, three legal entities independent from each other and each established in a different country as follows:

  • at least one independent legal entity established in a Member State; and
  • at least two other independent legal entities, each established in different Member States or Associated Countries.

Any legal entity, regardless of its place of establishment, including legal entities from non-associated third countries or international organisations (including international European research organisations) is eligible to participate (whether it is eligible for funding or not), provided that the conditions laid down in the Horizon Europe Regulation have been met, along with any other conditions laid down in the specific call topic.

A ‘legal entity’ means any natural or legal person created and recognised as such under national law, EU law or international law, which has legal personality and which may, acting in its own name, exercise rights and be subject to obligations, or an entity without legal personality.

Specific cases:

  • Affiliated entities — Affiliated entities (i.e. entities with a legal or capital link to a beneficiary which participate in the action with similar rights and obligations to the beneficiaries, but which do not sign the grant agreement and therefore do not become beneficiaries themselves) are allowed, if they are eligible for participation and funding.
  • Associated partners — Associated partners (i.e. entities which participate in the action without signing the grant agreement, and without the right to charge costs or claim contributions) are allowed, subject to any conditions regarding associated partners set out in the specific call conditions.
  • Entities without legal personality — Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees to protect the EU’s financial interests equivalent to those offered by legal persons.
  • EU bodies — Legal entities created under EU law including decentralised agencies may be part of the consortium, unless provided for otherwise in their basic act.
  • Joint Research Centre (‘JRC’)— Where provided for in the specific call conditions, applicants may include in their proposals the possible contribution of the JRC but the JRC will not participate in the preparation and submission of the proposal. Applicants will indicate the contribution that the JRC could bring to the project based on the scope of the topic text. After the evaluation process, the JRC and the consortium selected for funding may come to an agreement on the specific terms of the participation of the JRC. If an agreement is found, the JRC may accede to the grant agreement as beneficiary requesting zero funding or participate as an associated partner, and would accede to the consortium as a member.
  • Associations and interest groupings — Entities composed of members (e.g. European research infrastructure consortia (ERICs)) may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. However, if the action is in practice implemented by the individual members, those members should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible.

other eligibility criteria

In recognition of the opening of the US National Institutes of Health’s programmes to European researchers, any legal entity established in the United States of America is eligible to receive Union funding. Because the US contribution will be considered for the calculation of the EU contribution to the partnership, the concerned consortium of research funders from eligible EU Members States and Associated Countries must expressly agree to this participation.

The thresholds for each criterion will be 4 (Excellence), 4 (Impact) and 3 (Implementation). The cumulative threshold will be 12.

Beneficiaries may provide financial support to third parties. The support to third parties can only be provided in the form of grants. Financial support provided by the participants to third parties is one of the primary activities of the action in order to be able to achieve its objectives. Given the type of action and its level of ambition, the maximum amount to be granted to each third party is EUR 10.00 million.

Additional information

Topics

Disaster Prevention, Resilience, Risk Management, 
Health, Social Services, Sports

Relevance for EU Macro-Region

EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region

UN Sustainable Development Goals (UN-SDGs)

project duration

between 84 and 120 months

Additional Information

All proposals must be submitted electronically via the Funders & Tenders Portal electronic submission system (accessible via the topic page in the Search Funding & Tenders section). Paper submissions are NOT possible.

Proposals must be complete and contain all parts and mandatory annexes and supporting documents, e.g. plan for the exploitation and dissemination of the results including communication activities, etc.

The application form will have two parts:

  • Part A (to be filled in directly online) contains administrative information about the applicant organisations (future coordinator and beneficiaries and affiliated entities), the summarised budget for the proposal and call-specific questions;
  • Part B (to be downloaded from the Portal submission system, completed and then assembled and re-uploaded as a PDF in the system) contains the technical description of the project.

Annexes and supporting documents will be directly available in the submission system and must be uploaded as PDF files (or other formats allowed by the system).

The limit for a full application (Part B) is 70 pages.

The award criteria are described in General Annex D. The following exceptions apply: The thresholds for each criterion will be 4 (Excellence), 4 (Impact) and 3 (Implementation). The cumulative threshold will be 12.

Call documents

Horizon Cluster 1 2024-2024 WPHorizon Cluster 1 2024-2024 WP(1908kB)

Contact

National Contact Points for Horizon Europe
Website

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